KMID : 0606920150230030261
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Biomolecules & Therapeutics 2015 Volume.23 No. 3 p.261 ~ p.267
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Effect of Pioglitazone on Excitotoxic Neuronal Damage in the Mouse Hippocampus
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Lee Choong-Hyun
Yi Min-Hee Chae Dong-Jin Zhang Enji Oh Sang-Ha Kim Dong-Woon
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Abstract
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Pioglitazone (PGZ), a synthetic peroxisome proliferator-activated receptor ¥ã agonist, is known to regulate inflammatory process and to have neuroprotective effects against neurological disorders. In the present study, we examined the effects of 30 mg/kg PGZ on excitotoxic neuronal damage and glial activation in the mouse hippocampus following intracerebroventricular injection of kainic acid (KA). PGZ treatment significantly reduced seizure-like behavior. PGZ had the neuroprotective effect against KA-induced neuronal damage and attenuated the activations of astrocytes and microglia in the hippocampal CA3 region. In addition, MPO and NF¥êB immunoreactivities in the glial cells were also decreased in the PGZ-treated group. These results indicate that PGZ had anticonvulsant and neuroprotective effects against KA-induced excitotocix injury, and that neuroprotective effect of PGZ might be due to the attenuation of KA-induced activation in astrocytes and microglia as well as KA-induced increases in MPO and NF¥êB.
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KEYWORD
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Pioglitazone, Kainic acid, Neuroprotection, Hippocampus, Astrocyte, Microglia
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